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New Test Diagnoses Lyme Disease Within 15 Minutes
Some 300,000 people in the U.S. are diagnosed with Lyme disease every year. Caused by Borrelia burgdorferi and transmitted by the bite of infected Ixodes ticks, the disease if left untreated can cause serious neurologic, cardiac, and/or rheumatologic complications.
Current testing for Lyme disease, called the standard 2-tiered approach or the STT, involves running two complex assays (ELISA and western blot) to detect antibodies against the bacterium, and requires experienced personnel in a lab, and a few hours to carry out and interpret. A team led by Sam Sia, professor of biomedical engineering at Columbia Engineering, has developed a rapid microfluidic test that can detect Lyme disease with similar performance as the STT in a much shorter time—15 minutes.
“Our findings are the first to demonstrate that Lyme disease diagnosis can be carried out in a microfluidic format that can prov
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Vaccine Against RSV Could Be In Sight, Researchers Say
A vaccine for the common and sometimes deadly RSV (respiratory syncytial virus) has been elusive, but scientists say a new discovery puts them much closer to success.
A new study from The Ohio State University provides a potential blueprint for finding the immunological sweet spot – a vaccine weak enough that it doesn’t make people sick but strong enough that it prompts an ample immune response, ensuring that the body will recognize RSV as an intruder in the future, and quickly mount a protective defense.
In a study published today (Oct. 9, 2019) in the journal Nature Communications, researchers report success in knocking out an epigenetic modification known as N6-methyladenosine in RSV RNA – a technique that proved to tamp down the virus and prompt a robust immune response in cotton rats.
“We now have a novel target to go after, and are working with industry toward a vaccine,” said t
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Opinion: Son's 'Coming Out' Inspires Doctor To Focus On LGBTQ Care
Six years ago, the wheels of change started spinning in my home when my ninth grader said he identified as transgender. As his father, the most important thing for me to do was be there for him and show my support. As a physician, I wanted to know everything I could to help, so I could answer any questions he'd have during his transition journey. But everywhere I looked, no one had answers — not my colleagues at the clinic nor my insurance company. I felt helpless. It's my job to have the answers, but I quickly found the resources weren't there.
My frustration inspired me to do something. In 2017, I launched a clinic dedicated to LGBTQ care at my UnityPoint Health practice in Cedar Falls, Iowa. I wanted to design a place where my son, and others like him, felt welcomed and had access to personalized care. Statistics show one in four transgender people had a very negative experience with
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Substantial Variation In Uptake Of New Prescribing Guidance By GPs
Substantial variation exists between general practices in uptake of new prescribing guidance, with important implications for patient care and health expenditure, finds the largest analysis of its kind published by The BMJ today.
The findings show that most practices changed their behaviour, but some changed much later than others, leading to avoidable health service costs and poorer patient care.
Adopting new evidence into clinical practice is critical in a well performing healthcare system. The speed of uptake ("diffusion of change") is thought to vary over time, but previous work has focused on small samples, narrative descriptions, or analysis at only one time point.
To investigate this gap between evidence and practice further, researchers based in the UK and Canada, set out to determine how clinicians vary in their response to new treatment guidance, using an automated change de