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NEWS:

Detecting Long-Term Concussion In Athletes

Lawyers representing both sides in concussion lawsuits against sports leagues may eventually have a new tool at their disposal: a diagnostic signature that uses artificial intelligence to detect brain trauma years after it has occurred.

While the short-term effects of head trauma can be devastating, the long-term effects can be equally hard for patients. The symptoms may linger years after the concussion happened. The problem is it is often hard to say whether their symptoms are being caused by a concussion or other factors like another neurological condition or the normal aging process.

The only way to prove the presence of brain damage caused by concussion years after it occurred was through post-mortem examination. A means of diagnosing concussion in living patients, however, remained elusive.

A research team from Université de Montreal, The Montreal Neurological Institute and Hosp

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Soccer Boosts Bone Development In Boys

Playing soccer can improve bone development in adolescent boys, new research shows.

In a study comparing adolescent soccer players to swimmers, cyclists and a control group of boys not involved in regular sport, scientists at the University of Exeter found soccer led to significantly better bones after one year of training.

Adolescence is the key period for bone development, and poor development at this stage is linked to reduced peak bone mass (the amount of bone mass at the end of the skeletal maturation, around age 30), increased fracture risk and osteoporosis later in life.

Though swimming and cycling have proven health benefits, the scientists said their study "raises a question" about whether they are good for bone development due to the non-weight bearing training - and they say young swimmers and cyclists could benefit from more weight-bearing exercise in training regimes.

"O

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UMMS Researcher, Colleagues Develop Tumor-Targeting MRI Contrast Based On Human Protein

A team led by Gang Han, PhD, has designed a human protein-based, tumor-targeting Magnetic Resonance Imaging (MRI) contrast that can be easily cleared by the body. The discovery holds promise for clinical application, including early stage tumor detection because of the enhanced MRI contrast, according to Dr. Han, associate professor of biochemistry & molecular pharmacology at University of Massachusetts Medical School.

MRI is one of the most widely used, noninvasive and versatile imaging tools for clinical detection, staging and monitoring of malignancy, without the need for ionizing radiation or harmful radionuclides.

The most frequently employed contrast agents used in MRI are gadolinium (Gd)-based, since they do not provoke an immune response in cells. However, such compounds require high doses of intravenous administration and are retained in the body's organs.

In the search for a

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High-Speed Whole-Brain Imaging Improves Understanding Of Brain Disease

To fully understand brain function and dysfunction, it is important to be able to visualize changes in anatomy and activity in the whole brain. High-resolution brain imaging that can distinguish individual cells and quantitative comparison of acquired data are essential to show how the brain is affected by disease.

However, current attempts to image a whole mouse brain at a resolution high enough to gain detailed information take up to one week. While these approaches have revealed important insights into brain function, it is not possible to image and analyze multiple brains with these technologies. Comparing multiple brains is essential to understand neurobiological function and dysfunction in brain disorders.

Osaka University-led researchers have developed block-face serial microscopy tomography (FAST)--an imaging system that can image a whole mouse brain at high spatial resolution

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