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Self-Cannibalizing Mitochondria May Set The Stage For ALS Development
Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration that is seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking.
The discovery was so novel, the scientists needed to coin a new term to describe it: mitoautophagy, a collection of self-destructive mitochondria in diseased upper motor neurons of the brain that begin to disintegrate from within at a very early age. Upper motor neurons in the brain are responsible for initiating muscle movement and relaxation and are one of the first to break down in neurodegenerative diseases.
The study will be published on November 7 in the journal Frontiers in Cellular Neuroscience.
The phenomenon is observed mainly in one of the most common pathologies observed in neurodegenerative diseases, TDP-43 pathology,
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Physicians Create Guide For Identifying, Treating Vaping Lung Illness
As lung injuries from vaping continue to rise across the United States, Rochester physicians and New York health leaders developed a new tool to assist in the diagnosis and treatment of e-cigarette, or vaping, product use associated lung injury (EVALI).
The diagnostic/treatment algorithm, published in The Lancet Respiratory Medicine, complements and expands upon early guidance from the Centers for Disease Control and Prevention for managing the condition. It was created by pulmonary and toxicology experts at the University of Rochester and the New York State Department of Health.
"This illness has been vexing for physicians across the country and we continue to see people suffering from the dangerous effects of vaping," said Daniel Croft, M.D., M.P.H., pulmonologist at the University of Rochester Medical Center's Strong Memorial Hospital. "We expect the guide will help minimize missed
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Black And Elderly Patients Less Likely To Receive Lung Cancer Treatments
Only about 6 in 10 lung cancer patients in the United States receive the minimal lung cancer treatments recommended by the National Comprehensive Cancer Network guidelines, according to new research published online in the Annals of the American Thoracic Society.
In “Disparities in Receiving Guideline-Concordant Treatment for Lung Cancer in the United States,” Erik F. Blom, MD, and colleagues report that the likelihood of receiving the minimal treatments is even lower for black patients and the elderly.
The researchers based their findings on an analysis of 441,812 lung cancer cases diagnosed between 2010-2014 in the National Cancer Database.
“Comparability and generalizability of previous findings on this topic were limited,” said Dr. Blom, a researcher in the Department of Public Health at the Erasmus MC University Medical Center Rotterdam in the Netherlands, who had a guest affili
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Three-Drug Combo Improves Lung Function In Most Common Genetic Form Of Cystic Fibrosis
A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.
Earlier this month, the Food and Drug Administration approved the therapy based on the results of this international study, published today in the New England Journal of Medicine. A companion investigation appearing simultaneously in The Lancet reported on people with one or two copies of the mutation.
Dr. Raksha Jain, Associate Professor of Internal Medicine at UT Southwestern Medical Center, is corresponding author of the NEJM article and an investigator on The Lancet study. Dr. Jain is presenting both studies at the North American Cystic Fibrosis Conference in Nashville this week.
CF is a chronic, progressive, and frequently f