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COPD: Changes In The Lungs, Changes In The Microbiome

Coughing, breathing difficulties, and strong mucous production in the lungs are typical symptoms of COPD. The disease is often triggered by smoking, and, according to estimates from the World Health Organization (WHO), it could become the world's third most common cause of death in 2030. "COPD has various subtypes that, for example, can be verified by use of quantitative computer tomography (qCT)," explains PD Dr. Wolfgang zu Castell, head of the Research Unit Scientific Computing (ASC) at the Helmholtz Zentrum München. "We wanted to investigate if the microbiome in the lungs changes in a way that depends on these subtypes," adds Prof. Dr. Michael Schloter, head of the Research Unit for Comparative Microbiome Analyses (COMI) at the Helmholtz Zentrum München.

Microbiome and CT scans analyzed

For this purpose, scientists from the two research units examined samples gathered from nine hea

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After Watching Disturbing Video, CPAP Usage Soars

Like more than 20 million other Americans, John Brugger has been diagnosed with sleep apnea. He snored, tossed and turned, and struggled to breathe during the night, which often left him not only exhausted the next day, but also raised his risk of heart attack, stroke and car accidents. Fed up, Brugger went to his doctor, who suggested he use a CPAP machine, which delivers air through a face mask while he sleeps to keep his throat open with continuous positive airway pressure (CPAP).

Brugger tried it a few times, but like more than half of those who get CPAP machines, he simply stopped using it. "I didn't like it, honestly," said Brugger, a father of five from Commerce City, Colo. "It was bulky, and I had a hard time getting to sleep with it on my face," he said.

But after watching a dramatic and disturbing video of himself trying to sleep without his CPAP mask, Brugger has had a chang

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Sinus Disease Symptoms Improve 10 Years After Patients Quit Smoking

Patients with chronic rhinosinusitis (CRS) who quit smoking will see their condition improve over a period of about 10 years, according to the results of a new study led by the Sinus Center at Mass. Eye and Ear. The study, published online in Otolaryngology – Head and Neck Surgery, is not only the first to quantify the severity of symptoms and quality-of-life impact of smoking on CRS patients, but also estimates the timeline of reversal of the smoking effects on the sinuses after cessation for the first time. The findings may provide better motivation for patients suffering from chronic sinus disease to break the habit.

“Our study looked at clinically-meaningful metrics associated with CRS, measuring how bad symptoms are and how much medication was needed,” said senior author Ahmad R. Sedaghat, MD, PhD, a sinus surgeon at Mass. Eye and Ear and assistant professor of otolaryngology at

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Do Breathing Issues Hamper Exercise In Overweight Preteens?

Do overweight children have more breathing limitations, intolerance for exercise, and breathlessness when exercising than normal weight children, leading to possible misdiagnosis for conditions such as asthma?

Investigators with the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, a joint program of UT Southwestern Medical Center and Texas Health Resources, received a 5-year, $2.7 million grant to find out and are seeking preteen volunteers.

“Excess fat on the chest can put an unfavorable burden on the respiratory system during exercise, but it’s unclear whether that burden reduces their tolerance for exercise, makes breathing more difficult – a condition known as dyspnea on exertion, or contributes to other respiratory symptoms,” said Dr. Tony G. Babb, Professor of Internal Medicine in the Division of Pulmonary and Critical Care Medicine

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