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Nanoscale “Glass” Bottles Could Enable Targeted Drug Delivery
Tiny silica bottles filled with medicine and a special temperature-sensitive material could be used for drug delivery to kill malignant cells only in certain parts of the body, according to a study published recently by researchers at the Georgia Institute of Technology.
The research team devised a way to create silica-based hollow spheres around 200 nanometers in size, each with one small hole in the surface that could enable the spheres to encapsulate a wide range of payloads to be released later at certain temperatures only.
In the study, which was published on June 4 in the journal Angewandte Chemie International Edition, the researchers describe packing the spheres with a mixture of fatty acids, a near-infrared dye, and an anticancer drug. The fatty acids remain solid at human body temperature but melt a few degrees above. When an infrared laser is absorbed by the dye, the fatty a
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Pharmacist-Led Approach In Community Hospitals Can Cut Antibiotic Use
In small, community hospitals that don’t have resources for a dedicated staff to oversee the proper use of antibiotics, turning to staff pharmacists showed promise in a model study conducted by Duke Health.
The study, which included four community hospitals in North Carolina, demonstrated an approach that could be expanded to the nation’s wider network of small hospitals, where more than half of the U.S. population accesses care.
“This is a matter of major consequence, because up to 50% of antibiotic use in our study was inappropriate, meaning there was a better choice or the prescription was simply unnecessary,” said Deverick Anderson, M.D., director of the Duke Center for Antimicrobial Stewardship and Infection Prevention and lead author of the study publishing Friday in JAMA Network Open.
“We have to develop systems that are scalable and effective in helping reduce the improper or
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Surgeons Report Success In Reducing Opioid Prescribing Without Increasing Patients’ Pain
Having a hernia repaired, or an appendix or gallbladder removed, hurts. And for the past two decades, patients having these common operations in the U.S. have gone home from the hospital with prescriptions for dozens of opioid pills to ease that pain.
But with rising concern about the role of those pills in the national opioid epidemic, a new study shows how one state’s surgeons reduced the number of opioids they prescribed to thousands of patients -- without causing patients to feel more pain or less satisfied with their surgical experience.
In a new research letter in the New England Journal of Medicine, a team from the Michigan Opioid Prescribing Engagement Network reports the results of a collaborative effort to help surgical teams follow evidence-based opioid prescribing guidelines developed at the University of Michigan.
In just one year, teams at 43 hospitals across the state r
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Accredo's New Full-Service Specialty Pharmacy Offers Hawaii Residents Greater Access To High-Touch Pharmacy Care
Accredo, a specialty pharmacy that serves people who take medications for complex and rare conditions, today opened a new, full-service pharmacy for residents of Hawaii who require additional clinical and administrative support for their complex treatments and medications.
Located in Ala Moana-Kakaako, Accredo provides high-touch pharmacy care to people with chronic conditions such as multiple sclerosis, cancer and hemophilia.
The new pharmacy will serve all residents of Hawaii whose pharmacy benefit includes Accredo, including AlohaCare, a Hawaii-based, non-profit health plan with more than 65,000 members living on Oahu, Kauai, Molokai, Lanai, Maui and Hawaii Island.
The new pharmacy in Honolulu offers a range of services, including walk-in consultations with a pharmacist, home delivery via courier and mail, and site-of-care (or ambulatory) infusion center with onsite nurses. Oncol