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Can We Intercept Cancer? A New Frontier in Cancer Research
Imagine cancer as a line on a chalkboard. At the left is a healthy cell. Reading left to right, you can follow a cell’s journey as it begins to develop abnormalities, morphs to become a localized cancer, and finally metastasizes to an advanced cancer at the far side of the spectrum. “As a field, we’ve been spending a lot of time looking to the right. The opportunity now is to look to the left,” says Robert Vonderheide, MD, DPhil, director of the University of Pennsylvania’s Abramson Cancer Center and the John H. Glick Abramson Cancer Center Professor in the Perelman School of Medicine. “Can we intercept those precursor lesions before they become cancer?”
That is the promise of the burgeoning field of cancer interception. The goal of interception is to catch, or intercept, cancer cells as they begin to develop into pre-cancers or very early cancers, and halt or reverse that process. The
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Invention: A Blood Test to Unlock Prostate Cancer Mysteries
Cedars-Sinai Cancer investigators have developed a new nanotechnology-based test that can detect and profile prostate cancers--even in microscopic amounts. Their work, published in the peer-reviewed journal nanotoday, suggests that this "liquid biopsy" test could spare many patients unnecessary treatment-related side effects, directing them instead to effective therapies that could prolong their lives.
"This research will revolutionize the liquid biopsy in prostate cancer," said Edwin Posadas, MD, medical director of the Urologic Oncology Program and co-director of the Experimental Therapeutics Program in Cedars-Sinai Cancer. "The test is fast, minimally invasive and cost-effective, and opens up a new suite of tools that will help us optimize treatment and quality of life for prostate cancer patients."
Cancer of the prostate, a walnut-sized gland just below the bladder, is the most c
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Sedentary Time May Significantly Enlarge Adolescents’ Heart
In adolescents, sedentary time may increase heart size three times more than moderate-to-vigorous physical activity, a paper published in the Scandinavian Journal of Medicine & Science in Sports concludes. The study was conducted in collaboration between the University of Bristol in the UK, the University of Exeter in the UK, and the University of Eastern Finland. The researchers explored the associations of sedentary time, light physical activity, and moderate-to-vigorous physical activity with cardiac structure and function.
Recent World Health Organization reports and guidelines note that more than 80% of adolescents across the globe have insufficient physical activity per day. Physical inactivity has been associated with several non-communicable diseases in adults such as cardiovascular diseases, type 2 diabetes, and cancer. In the pediatric population, the majority of movement beha
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Nurturing Nurse Executives
To help fill a leadership gap, The Paul Merage School of Business is launching an online certificate program for chief nursing officers
The COVID-19 pandemic put extreme stress on society, healthcare and nursing, with repercussions that will be felt for decades. Many nurses took early retirement, and others exited the profession altogether, leaving numerous institutions facing personnel challenges and succession issues, resulting in a shortage of executive leadership.
In response, UCI’s Paul Merage School of Business will launch an online chief nursing officer certificate program on June 14, in partnership with Emeritus, a prominent educational platform designed to prepare individuals for executive roles.
“The focus of the program is to give people who have engaged in clinical leadership the means to develop the skill set to become the next generation of executives in healthcare,” s