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Interferon Does Not Improve Outcomes For Hospitalized Adults With Covid-19
A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia.
In addition, in a subgroup of patients who required high-flow oxygen, investigators found that interferon beta-1a was associated with more adverse events and worse outcomes. These findings were published today in the journal The Lancet Respiratory Medicine.
The study, called the Adaptive COVID-19 Treatment Trial 3 (ACTT-3), took place from August 5, 2020 to December 21, 2020. It was sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Interferon beta-1a has the same amino acid sequence as a naturally occurring protein called interferon beta, which is in a class of proteins called type 1 interf
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Brain Activity Patterns After Trauma May Predict Long-Term Mental Health
The way a person’s brain responds to stress following a traumatic event, such as a car accident, may help to predict their long-term mental health outcomes, according to research supported by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. The research, published in the American Journal of Psychiatry, is part of the NIMH-funded AURORA study(link is external), a large-scale, multisite study that followed more than 3,000 people for up to a year after exposure to a traumatic event.
Evidence from previous studies suggests that it’s common for people to show a wide range of responses after a traumatic experience, such as a natural disaster or serious accident. One person may show initial symptoms that diminish naturally over time, while another may have long-lasting symptoms that make it difficult to carry out everyday activities. These different re
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The Facebook Whistleblower Report - A Response From Children and Screens: Institute of Digital Media and Child Development
In its article “Facebook Knows Instagram Is Toxic for Teen Girls, Company Documents Show,” the Wall Street Journal recently revealed that Facebook has long known about the deleterious mental health effects of its social media sites on teens, and most notably girls, based on the company’s own data. The WSJ’s exposé of the “Facebook Files” has shocked millions of people. This revelation did not shock us or other experts and researchers studying youth social media use.
For the past decade, hundreds of studies have documented that highly visual social media, such as Instagram and Facebook, can negatively affect teen girls’ mental health. When studies focus on simple measures of screen-time, they often find small but statistically significant associations between time on social media and depressive symptoms. However, studies that have examined how adolescents use social media tell a diffe
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Working Mothers Who Feel In Control Of Schedule More Likely To Embrace Healthy Habits
Working, single mothers who feel in control of their schedules are more likely to fit in healthy habits like exercise, according to new research from Rice University, the Virginia Polytechnic Institute and State University, and the Georgia Institute of Technology.
In their study, researchers followed more than 100 single, working mothers over a week and examined how their different mindsets while balancing work and family tasks affected the likelihood of exhibiting healthy behaviors during their downtime. They found that family demands on working mothers make exercise much less likely when compared to people with fewer responsibilities. However, individual perspective made a difference.
"Regardless of how busy a mother was, when she lived in the moment and felt like she was in control of her schedule, she was more likely to make time for exercise," said Danielle King, an assistant pr