Login / Register

Username:


Password: [Lost?]



New User? Click here for your FREE subscription



Orthopedic and Rehabilitation Specialists
Orthopedic and Rehabilitation Specialists Orthopedic and Rehabilitation Specialists

Follow Us


NEWS-Line on Twitter NEWS-Line on Facebook NEWS-Line on Google+ NEWS-Line on LinkedIn NEWS-Line on Pinterest


Orthopedic and Rehab Conferences &
Educational Opportunities





June 2 - 05

2019 NADONA 32ND ANNUAL CONFERENCE

NADONA

June 11 - 14

Skin, Bones, Hearts & Private Parts 2019 Destin CME/CE Conference

Skin, Bones, Hearts & Private Parts

June 12 - 15

NEXT Conference & Exposition

American Physical Therapy Association

June 18 - 23

2019 AANP National Conference

American Association of Nurse Practitioners

July 19 - 21

ASHA Connect 2019

American Speech-Language-Hearing Association

More Events

Rutgers Study Uncovers Cause Of Bone Loss In Joint Implant Patients | NEWS-Line for Physical Therapists & PT Assistants

Rutgers Study Uncovers Cause Of Bone Loss In Joint Implant Patients


Source:

Rutgers researchers have discovered the long-sought reason that many people with joint replacements experience harmful inflammation and bone loss.

Their finding, published in Nature Materials, may pave the way for new therapies to reduce pain and prevent the need for follow-up surgery.

As many as 15% of joint replacements will fail, often requiring revision surgery to replace the implant. A major contributing factor is microparticles released from the prosthetic devices — known as “wear debris” — which are thought to promote inflammation, leading to pain, disappearance of bone tissue, loosening of the implant and ultimately failure of the implant to affix to the bone.

But, until now, the specific pathways through which these particles promote inflammation have been unclear. The Rutgers study found white blood cells, called macrophages, respond to the particles as if they were harmful invaders and engulf them. But the cells then die, and secrete a specific molecule that triggers an even stronger immune response – including inflammation which can cause tissue damage and bone destruction which leads to loosening of the implants.

“Bone degradation can occur within 10-15 years and often requires complex revision surgery to replace the implant and treat bone loss,” said lead author William Gause, director of the Center for Immunity and Inflammation at Rutgers New Jersey Medical School. “However, many people start experiencing pain from this inflammation shortly after surgery. They are prescribed medications for the pain, but the loosening continues.”

Researchers can use the Rutgers study to identify ways to regulate the inflammation and bone degradation associated with these released particles, potentially without harming components of the patient’s immune response needed for protection against infectious pathogens, Gause said.

More generally, these studies reveal new insights into how inert and sterile microparticles, including pollutants such as diesel exhaust particles or silica, can cause robust and harmful inflammation, ultimately leading to disease. “Although we typically think of infectious agents or toxins as causing disease, apparently the response of the body to these particles, which have essentially no intrinsic activities, can result in considerable tissue damage and pathology,” Gause said.

[photo credit: KimvdLinde; WikiCommons]


Post not cached because it doesn't exist


Share This!


Orthopedic and Rehab Jobs






Director of Nursing

Iowa County Bloomfield Healthcare and Rehabilitation Center
Dodgeville, Wisconsin

Physical Therapist

Memorial Medical Center
New Mexico

Nurse Practitioner

Harvard University Health Services
Cambridge, Massachusetts

Nurse Practitioner

Oak Valley Hospital
Oakdale, California

Orthopedic Physician Assistant

EmergeOrtho | Blue Ridge Division
Asheville area, North Carolina

Speech Therapy

Brefeld Physical Therapy
Belleville, Illinois

More Jobs
(Dismiss) Thank you for visiting NEWS-Line! Please sign up, login, or follow us on your favorite social networks
to receive custom tailored eNews, job listings, and educational opportunities for your specific profession.