Login / Register


Password: [Lost?]

New User? Click here for your FREE subscription

Acute and Ambulatory Care Professionals
Acute and Ambulatory Care Professionals Acute and Ambulatory Care Professionals

Follow Us

NEWS-Line on Twitter NEWS-Line on Facebook NEWS-Line on Google+ NEWS-Line on LinkedIn NEWS-Line on Pinterest

Acute and Ambulatory Care Conferences &
Educational Opportunities

Oct. 20 - 27

Skin, Bones, Hearts & Private Parts 2019 Caribbean Cruise CME/CE Conference

Skin, Bones, Hearts & Private Parts

Oct. 21 - 24

Skin, Bones, Hearts & Private Parts 2019 Orlando CME/CE Conference

Skin, Bones, Hearts & Private Parts

Oct. 31 - Nov. 2

National Student Conclave (NSC)

American Physical Therapy Association

Nov. 12 - 15

Skin, Bones, Hearts & Private Parts 2019 Las Vegas CME/CE Conference

Skin, Bones, Hearts & Private Parts

Dec. 1 - 06

105th Scientific Assembly and Annual Meeting

Radiological Society of North America

More Events

Two-In-One Contrast Agent For Medical Imaging | NEWS-Line for Radiology Professionals

Two-In-One Contrast Agent For Medical Imaging


Magnetic resonance imaging (MRI) visualizes internal body structures, often with the help of contrast agents to enhance sensitivity. A Belgian team of scientists has now developed a bimodal contrast agent suited for two imaging techniques at once, namely, MRI and a technique called photoacoustic imaging. The use of only one contrast agent for two imaging techniques improves the sensitivity of both, with only little impact on the patient's body.

MRI is a widely used technique in medicine and research and is known for its good resolution. Structures down to a hundredth of a millimeter can be resolved. However, sensitivity, the ability to detect something at all, is sometimes an issue. Therefore, contrast agents are often administered to improve the clarity by which the structures can be seen.

The results of MRI can also be improved in combination with complementary imaging methods, which focus on different aspects. However, most imaging tools require the presence of probes and dyes, but applying first a contrast agent, and then a second drug may cause more risks for the patient. This inspired Sophie Laurent, a professor at the University of Mons, Belgium, and her team to develop so-called bimodal contrast agents - agents that would serve both tools at once.

MRI contrast agents typically contain gadolinium, a paramagnetic element that enhances the signal of the elements nearby. Free gadolinium can be harmful, but it is held tightly within the structure of an organic molecule. Laurent's idea was to directly join the gadolinium agent with the probe used for the second imaging technique.

The team chose photoacoustic imaging (PAI), a highly sensitive and rather new imaging method that measures the heat response in a tissue to laser pulses. The method is, like MRI, non-invasive, but a special organic dye must be present that absorbs laser light applied from the outside. This technique would clearly enhance MRI sensitivity, the authors thought. Dysfunctions in the skin and below would be detected with unprecedented clarity.

To join the gadolinium agent with the organic dye, the scientists chose the natural amino acid lysin as a linker. Lysin is special among the amino acids. It is a rather long molecule that can bind to two other molecules at both ends. The scientists successfully linked an MRI agent called Gd-PCTA with a PAI probe with the name ZW800-1. And there is another option. Apart from the two connections, lysin owns a third connectivity, which could be of use in the future. The scientists imagine adding an additional biovector, for example, a peptide that recognizes specifically a biological disorder--this would make the now bimodal probe trimodal.

The bimodal probe enhanced the MRI contrast as strongly as a commercial MRI agent. And it gave the same photoacoustic signal as the original PAI probe. This means the probe is a two-in-one agent, which facilitates the combination of MRI and other medical imaging techniques. The next step would be to test it in real organisms.


Photo Credit:Pixbay

Post not cached because it doesn't exist

Share This!

Acute and Ambulatory Care Jobs

Physical Therapist

Atrius Health
Peabody, Massachusetts

Physician Assistant

Neurosurgical Medical Clinic, Inc.
San Diego, California

Nurse Practitioner

Oak Valley Hospital
Oakdale, California

Director of Nursing

Water’s Edge Health and Rehabilitation at Sandhill Cove Retirement Living
Palm City, Florida

Mid-level Provider

Northwest Renal Clinic
Portland, Oregon

Respiratory Therapists

Select Specialty Hospital
Ohio & Michigan

More Jobs
(Dismiss) Thank you for visiting NEWS-Line! Please sign up, login, or follow us on your favorite social networks
to receive custom tailored eNews, job listings, and educational opportunities for your specific profession.