Login / Register

Username:


Password: [Lost?]



New User? Click here for your FREE subscription



Healthcare Professionals
Healthcare Professionals Healthcare Professionals

Follow Us


NEWS-Line on Twitter NEWS-Line on Facebook NEWS-Line on Google+ NEWS-Line on LinkedIn NEWS-Line on Pinterest


Healthcare Conferences &
Educational Opportunities









Ongoing

Skin, Bones, Hearts & Private Parts - CME NOW OnDemand

Skin, Bones, Hearts & Private Parts

Aug. 30 - Sept. 2

Skin, Bones, Hearts & Private Parts - Chicago

Skin, Bones, Hearts & Private Parts

Sept. 13 - 16

Skin, Bones, Hearts & Private Parts - Pensacola

Skin, Bones, Hearts & Private Parts

Sept. 16 - 18

2022 SPAP Annual CME Conference

The Society for Physician Assistants in Pediatrics

Oct. 4 - 07

Skin, Bones, Hearts & Private Parts - San Antonio

Skin, Bones, Hearts & Private Parts

More Events

Dialysis Patients: Need For Optimisation Of Stroke Prevention | NEWS-Line for Healthcare Professionals
 


Dialysis Patients: Need For Optimisation Of Stroke Prevention


Source:

The anticoagulants currently used to prevent strokes in dialysis patients with atrial fibrillation do not provide adequate protection for this group. This is the finding of a study led by Oliver Königsbrügge and Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital, which was conducted in collaboration with seven dialysis centres in Vienna.

People with atrial fibrillation, an irregular heartbeat often associated with an excessively rapid or slow heart rate, have a greatly increased risk of stroke. The VIVALDI study (Vienna investigation of atrial fibrillation and thromboembolism in patients with atrial fibrillation on hemodialysis), led by Oliver Königsbrügge and Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital, highlights the need for action to prevent strokes in dialysis patients.

"The proportion of patients with atrial fibrillation is particularly high among haemodialysis patients, being in excess of 25%. Strokes and other cardiovascular events contribute significantly to mortality," explains Cihan Ay from the Department of Medicine I at MedUni Vienna and Vienna General Hospital. "Analysis of cardiovascular events that occurred during the observation period showed that, contrary to expectations, those patients who received anticoagulation treatment with the vitamin K antagonist phenprocoumon showed no benefit in terms of a reducing strokes but did have a higher rate of major bleeding."

The VIVALDI study was conducted in collaboration with seven dialysis centres in Vienna. A cohort of 625 haemodialysis patients was observed over a maximum period of 45 months. The incidence of thromboembolic events (strokes and systemic embolisms) was 4.8% per year in patients with atrial fibrillation. 8.4% of patients a year suffered major bleeding. "The high overall rate of thromboembolic complications confirms the need for action to provide haemodialysis patients with anticoagulation therapy that is equally effective in preventing strokes and other thromboembolic complications and safe to administer in terms of bleeding risk," says Ay.

Stroke prevention in atrial fibrillation is well researched among the general population. Based on study results, medication with drugs from the class of direct oral anticoagulants (DOAC) has been established as effective for several years now. This type of medication has so far been withheld from patients with permanent kidney failure and requiring dialysis due to a lack of relevant studies. Currently, only drugs from the class of vitamin K antagonists are approved as oral anticoagulants for haemodialysis patients in German-speaking countries. Clinical trials are currently ongoing into the use of direct oral anticoagulants (DOAC) in haemodialysis patients. "It would appear that there is a need to improve current clinical practice for preventing strokes in haemodialysis patients. We therefore eagerly await the results of the clinical trial," says Ay.

Service: Journal of Thrombosis and Haemostasis
Anticoagulation use and the risk of stroke and major bleeding in patients on hemodialysis: From the VIVALDI, a population-based prospective cohort study. Oliver Königsbrügge, Hannah Meisel, Aljoscha Beyer, Sabine Schmaldienst, Renate Klauser-Braun, Matthias Lorenz, Martin Auinger, Josef Kletzmayr, Manfred Hecking, Wolfgang C. Winkelmayer, Irene Lang, Ingrid Pabinger, Marcus Säemann, Cihan Ay.
Link: https://doi.org/10.1111/jth.15508

Medical University of Vienna - short profile
Medical University Vienna (MedUni Vienna) is one of the most traditional medical education and research facilities in Europe. With almost 8,000 students, it is currently the largest medical training centre in the German-speaking countries. With 6,000 employees, 30 departments and two clinical institutes, 12 medical theory centres and numerous highly specialised laboratories, it is also one of Europe's leading research establishments in the biomedical sector.

Source: Medical University of Vienna






Share This!


Healthcare Jobs




Bilingual Nurse Case Manager, Eugene (Hiring Bonus $1,500) - Licensed Practical Nurse, Eugene (Hiring Bonus $1,500) - RN Medical Case Manager, Eugene (Hiring Bonus $1,500) - RN Medical Case Manager, Salem (Hiring Bonus $1,500)

HIV Alliance
Oregon

Physician Assistant

Orthopedic Surgical Specialists
Burbank, California

Nurse Practitioner

Orthopedic Surgical Specialists
Burbank, California

Occupational Therapist Pediatric

Children's Therapy Center
Apple Valley, MN

Pediatrics Infectious Diseases-In Residence

University of California Los Angeles
Los Angeles, CA

Part Time General Dentist

Mid America Health
South Bend, IN

More Jobs
(Dismiss) Thank you for visiting NEWS-Line! Please sign up, login, or follow us on your favorite social networks
to receive custom tailored eNews, job listings, and educational opportunities for your specific profession.