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U.S. Blood Donations Are Safe Under Current Covid-19 Screening Guidelines | NEWS-Line for Healthcare Professionals

U.S. Blood Donations Are Safe Under Current Covid-19 Screening Guidelines


A new study by researchers at the National Institutes of Health and their colleagues has found that SARS-CoV-2, the virus that causes COVID-19, does not appear to pose a threat to the safety of the nation’s blood supply. The analysis, published in Transfusion(link is external), supports current donor screening guidelines, including those used by the U.S. Food and Drug Administration(link is external), that do not require testing blood samples for the SARS-CoV-2 virus but do require that donors be screened for physical symptoms of COVID-19 and for infections that occurred within 14 days of the blood donation. The blood of donors with recent COVID-19 infections, or who develop infections after recent donations, cannot be used.

After reviewing test results for the presence of SARS-CoV-2 in thousands of blood donations across the country, researchers found no reason to alter the current blood donor screening practices that are in place because of the COVID-19 pandemic.

“This finding is good news for thousands of patients who may need a blood transfusion because of surgery or a disease that causes anemia, such as a rare blood-related condition or leukemia,” said Simone Glynn, M.D., M.P.H., chief of the Blood Epidemiology and Clinical Therapeutics Branch at the National Heart, Lung, and Blood Institute (NHLBI), which conducted the study along with National Institute of Allergy and Infectious Diseases (NIAID).

The new analysis is based on 17,995 pools of donated blood, representative of 257,809 single blood donations collected between March and September 2020 from six U.S. metropolitan regions. Researchers concluded the likelihood of a transfusion recipient receiving blood with trace amounts of SARS-CoV-2 was approximately .001% – a little over 1 in 100,000 – and that the likelihood of SARS-CoV-2 transmission by blood transfusion was insignificant compared to airborne transmission.

Highly sensitive nucleic acid amplification tests, which have been documented to be 99.96% effective at detecting genetic components of the virus in blood, were used to screen blood donations. Of the thousands of samples tested, just three came back positive, all with very low concentrations of the virus.

“Other studies have shown that in rare cases where a blood sample tested positive, transmission by blood transfusion has not occurred,” said Sonia Bakkour, Ph.D., a scientist at the Vitalant Research Institute and part of the research team that analyzed the blood. She is also a scientist at the Department of Laboratory Medicine at the University of California, San Francisco. “Therefore, it appears safe to receive blood as a transfusion recipient and to keep donating blood, without fear of transmitting COVID-19 as long as current screenings are used.”

Bakkour and researchers started testing blood samples from blood collection centers to determine if SARS-CoV-2 could be detected in the blood of healthy donors and potentially transmitted to patients. Blood donors may donate only if they have no disease symptoms, but it was possible that they could be infected with SARS-CoV-2 and have no symptoms, be infected but not yet show physical symptoms, or have recovered from COVID-19, but still have lingering traces of the virus. Researchers wanted to know if any of these possibilities posed concerns for the blood supply.

The conclusion that SARS-CoV-2 does not threaten the safety of the nation’s blood supply under current guidelines mirrors results of similar studies conducted in Korea, Pakistan, China, and France. Those studies found that among the rare cases in which SARS-CoV-2 was detected in a blood donation, it contained a low viral load and did not result in transmission of COVID-19.

The study was conducted by the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS) Program. The NHLBI REDS Program conducts research to evaluate and improve the safety and availability of the nation’s blood supply, as well as the safety and effectiveness of blood transfusion therapies.

In addition, the program also addresses potential emerging threats to the blood supply, which is why early in 2020, the REDS Epidemiology, Surveillance and Preparedness of the Novel SARS-CoV-2 (RESPONSE)(link is external) project

About the National Heart, Lung, and Blood Institute (NHLBI): NHLBI is the global leader in conducting and supporting research in heart, lung, and blood diseases and sleep disorders that advances scientific knowledge, improves public health, and saves lives. For more information, visit www.nhlbi.nih.gov..

About the National Institute for Allergy and Infectious Diseases (NIAID): NIAID conducts and supports research — at NIH, throughout the United States, and worldwide — to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. For more information, visit https://www.niaid.nih.gov/.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov..

NIH…Turning Discovery Into Health®

Source: National Institutes of Health

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