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Cancer Prevention With HPV Vaccination | NEWS-Line for Pediatric and Child Health Specialists

Cancer Prevention With HPV Vaccination


Cervical cancer is preventable and is caused by persistent infection with Human Papillomavirus (HPV). Most sexually active adults will be infected with one or more types of HPV at some point in their lives and most of the time, those individuals will not know that they were ever infected. The peak age of having HPV infection is in the mid twenties and the risk for invasive cervical cancer begins to rise in the mid forties. The majority of HPV infections will be cleared to undetectable levels by 24 months, though some individuals will not clear the infection. Over time, there is a risk of the development of true precancerous lesions of the cervix, if the virus persists. The time from pre-cancer to cancer is in the range of 10 to 15 years and that allows for the detection of treatable pre-cancers and the prevention of invasion to cancer. The role of HPV in cervical cancer is well understood and it is now known that HPV types 16 and 18 cause the majority of cervical cancer, and HPV 16 also causes 90% of anal cancer. It does not require anal intercourse to have HPV in the anal canal. The role of HPV in non-genital cancers of the head and neck is also well understood and the incidence of those HPV related cancers is rising.

The HPV vaccines came to market after FDA approval in 2006 and the 9-valent vaccine has replaced the original quadrivalent and most of the bivalent vaccine use in the United States. Uptake of vaccination in age appropriate young men and women has been slow in spite of its role as a cancer prevention vaccine. In a report published by the CDC in 2015, it was noted that 4 out of 10 girls and 6 out of 10 boys had not started the vaccine series. The principal roadblock in this poor utilization has been said to be the failure of healthcare providers to recommend the vaccine. The vaccine was seen in the pivotal studies to prevent cervical, vulvar, vaginal and anal pre-cancer which serves as a surrogate marker for the prevention of cancer.

The current recommendation by the Advisory committee on Immunization Practice (ACIP) is:

Routine and catch–up age groups
Can be started at age 9
Females through age 26
Males through age 21 who were not adequately vaccinated previously
Males age 22 through 26 may be vaccinated

There are new recommendations on the number of doses that are necessary for effective acquired immunity. These recommendations address the more robust immune response when the vaccine is given to the younger men and women.

Continue this article at https://www.skinbonescme.com/2018/01/cancer-prevention-hpv-vaccination/

See Nancy Berman, MSN, ANP-BC, NCMP, FAANP speak in 2018 at a Skin, Bones, Hearts & Private Parts event in Phoenix/ScottsdaleMyrtle BeachPensacola, or Las Vegas.

NEWS-Line readers registering for any of these events will get $50 off when using promotional code NL2018 at checkout.

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