Cardiovascular & Pulmonary Rehabilitation Specialists Cardiovascular & Pulmonary Rehabilitation Specialists
    eNews      Latest News     Job Board     Conferences & Education     Featured Q&As     Post Your Resume     Break Room
Sign up for a Free Subscription
SIGN IN

Login to manage your
subscriptions & profile

Username:
Password: [Lost?]

New subscriber?
Free Subscription




Cardio & Pulmonary Conferences, Events, and Education

Cardio & Pulmonary Conferences &
Educational Opportunities

Vascular Laboratory: Advanced Topics for Vascular Specialists and Other Healthcare Professionals
04/26/2014 - 04/27/2014
UC Davis Health System, Office of CME, UC Davis Vascular Care Center

2014 CSRC State Conference
04/30/2014 - 05/02/2014
Colorado Society for Respiratory Care

28th Advances in Respiratory Care Conference
05/15/2014 - 05/16/2014
American Lung Association in Nevada

ATS 2014 International Conference
05/16/2014 - 05/21/2014
American Thoracic Society

ISRC Annual Conference 2014
05/28/2014 - 05/30/2014
Illinois Society for Respiratory Care

More Events



Related Terms:
cardio , pulmonary , vascular , thoracic , heart , lungs , sleep apnea , asthma , respiratory
How Red Wine May Shield Brain from Stroke Damage | NEWS-Line for Speech-Language Pathologists & Audiologists
04/29/2010
NEWSRoom | Source:  

How Red Wine May Shield Brain from Stroke Damage



Researchers at Johns Hopkins say they have discovered the way in which red wine consumption may protect the brain from damage following a stroke.

Two hours after feeding mice a single modest dose of resveratrol, a compound found in the skins and seeds of red grapes, the scientists induced an ischemic stroke by essentially cutting off blood supply to the animals’ brains. They found that the animals that had preventively ingested the resveratrol suffered significantly less brain damage than the ones that had not been given the compound.

Sylvain Doré, PhD, an associate professor of anesthesiology and critical care medicine and pharmacology and molecular sciences at the Johns Hopkins University School of Medicine, says his study suggests that resveratrol increases levels of an enzyme (heme oxygenase) already known to shield nerve cells in the brain from damage. When the stroke hits, the brain is ready to protect itself because of elevated enzyme levels. In mice that lacked the enzyme, the study found, resveratrol had no significant protective effect and their brain cells died after a stroke.

“Our study adds to evidence that resveratrol can potentially build brain resistance to ischemic stroke,” says Doré, the leader of the study, which appears online in the journal Experimental Neurology.

Red wine has gotten a lot of attention lately for its purported health benefits. Along with reducing stroke, moderate wine consumption has been linked to a lowered incidence of cardiovascular disease—the so-called French paradox. Despite diets high in butter, cheese and other saturated fats, the paradox goes, the French have a relatively low incidence of cardiovascular events, which some have attributed to the regular drinking of red wine.

Doré cautions against taking resveratrol supplements, available alongside vitamins and minerals and on websites touting its benefits, because it is unclear whether such supplements could do harm or good. He has not tested resveratrol in clinical trials. And while resveratrol is found in red grapes, it’s the alcohol in the wine that may be needed to concentrate the amounts of the beneficial compound. Doré also cautions that drinking alcohol carries risks along with potential benefits.

He also notes that even if further research affirms the benefits of red wine, no one yet knows how much would be optimal to protect the brain, or even what kind of red wine might be best, because not all types contain the same amount of resveratrol. More research is needed, he says.

Doré says his research suggests that the amount needed could end up being quite small because the suspected beneficial mechanism is indirect. “Resveratrol itself may not be shielding brain cells from free radical damage directly, but instead, resveratrol, and its metabolites, may be prompting the cells to defend themselves,” he suggests.

“It’s not likely that brain cells can have high enough local levels of resveratrol to be protective,” he says. The resveratrol is needed to jump-start this protective enzymatic system that is already present within the cells. “Even a small amount may be sufficient,” Doré says.

Doré says his ongoing research also suggests some therapeutic benefits to giving resveratrol to mice after a stroke to limit further neuronal damage.

The research was supported in part by grants from the National Institutes of Health, the Wine Institute and the ABMR Foundation.




Share This!






Short Link: http://www.news-line.com/?s158351
Copy




comments powered by Disqus


Healthcare Jobs

Healthcare Jobs

Home Care Physical Therapist
Upper Perk & New Hope Physical Therapy & Sports Rehab
Philadelphia suburbs (Pennsburg), Pennsylvania

COTA or OTR/Hand Therapist
Institute For Hand & Upper Extremity Rehabilitation
Doylestown, Pennsylvania

FULL TIME, Occupational Therapist
Mountain View Nursing and Rehabilitation Centre
New Paltz, New York

Certified Registered Nurse Practitioner
Renfrew Center
Philadelphia, Pennsylvania

Nurse Practitioners
Jersey Rehab PA - Belleville
New York

Nurse Practitioners
Jersey Rehab PA - Belleville
New Jersey

More Jobs
(Dismiss) Thank you for visiting NEWS-Line! Please sign up, login, or follow us on your favorite social networks
to receive custom tailored eNews, job listings, and educational opportunities for your specific profession.

HOME | GENERAL INFORMATION | READER SERVICES | ADVERTISER SERVICES | RSS DIRECTORY | CONTACT US
Copyright ©2014 NEWS-Line Publishing