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Archive for the ‘Lab’ Category

Analysis Of Spider Venom Reveals Seven Promising Compounds With Potential To Relieve Chronic Pain

Part of the search for new medicines has focused on the world's 45,000 species of spiders, many of which kill their prey with venoms that contain hundreds -- or even thousands -- of protein molecules. Some of these molecules block nerve activity.
Source: © BVDC / Fotolia

New research shows that seven compounds of the countless found in spider venom block a key step in the body’s ability to pass pain signals to the brain. The hunt for a medicine based on just one of these compounds, which would open up a new class of potent painkillers, is now a step closer [...]

Newly Discovered Hormone Mimics The Effects Of Exercise

Mouse and cheese (stock image).
Source: © Emilia Stasiak / Fotolia

Scientists at the USC Leonard Davis School of Gerontology have discovered a new hormone that fights the weight gain caused by a high-fat Western diet and normalizes the metabolism — effects commonly associated with exercising. Hormones are molecules that act as the body’s signals, triggering various physiological responses. The newly discovered hormone, dubbed “MOTS-c,” primarily [...]

Sun Damage Causes Genetic Changes That Predispose Children And Adolescents To Melanoma

The St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project found that melanoma in some adolescent and adult patients involves many of the same genetic alterations and would likely respond to the same therapy. Source: Peter Barta, St. Jude Children's Research Hospital

The St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project found that melanoma in some adolescent and adult patients involves many of the same genetic alterations and would likely respond to the same therapy. The research appears in the issue of the Journal of Investigational Dermatology. The similarities involved adolescents with conventional melanoma tumors [...]

Simulating The Potential Spread Of Measles

A free, mobile-friendly tool called FRED lets users simulate potential measles outbreaks in cities across the country. Source:  University of Pittsburgh Graduate School of Public Health

To help the public better understand how measles can spread, a team of infectious disease computer modelers at the University of Pittsburgh has launched a free, mobile-friendly tool that lets users simulate measles outbreaks in cities across the country. The tool is part of the Pitt team’s Framework for Reconstructing Epidemiological Dynamics, or FRED, that [...]

Reviving Drugs With Anti-Stroke Potential, Minus Side Effects

Schematic representation of the NMDA receptor complex. NMDA receptor antagonists can have beneficial effects in animal models of stroke, but also have pronounced side effects such as disorientation and hallucinations.
Source: Image courtesy of Emory Health Sciences

In the 1990s, neuroscientists identified a class of drugs that showed promise in the area of stroke. NMDA receptor antagonists could limit damage to the brain in animal models of stroke. But one problem complicated testing the drugs in a clinical setting: the side effects included disorientation and hallucinations. Now researchers have found a potential [...]

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